Claude Libert lab

Prof. Dr. Claude Libert

Tel: +32 9 33 13 700
Fax: +32 9 221 76 73

Research topic

The lab of Prof. Libert is focusing on the IECs in systemic acute lethal inflammation (SIRS) and sepsis. They apply several mouse models to trigger SIRS, using TNF, LPS or kidney ischemia/reperfusion, and Cecal Ligation and Puncture to induce sepsis. By means of RNASEQ, electron microscopy and FACS, and with a focus on TNF receptors and glucocorticoids, they zoom iin into the biology of ER stress, cell death, autophagy, but alsos microbiome and metabolism to find new drug targets for sepsis.

Areas of expertise

  • Cytokine biology
  • Inflammation models in mice
  • Sepsis models in mice
  • Nuclear receptors
  • Generation of mouse mutants

Selected publications

  1. Steeland et al. Efficient analysis of mouse genome sequences reveal many nonsense variants
    Proc Natl Acad Sci U S A 113, 5670-5675, 2016.
  2. Puim├Ęge et al. Glucocorticoid-induced MicroRNA-511 protects against TNF by down-regulating TNFR1
    EMBO Mol. Med., 7, 1004, 2015.
  3. Van Hauwermeiren et al. TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction
    Mucosal Immunology, 2014, 8, 828.
  4. Van Hauwermeiren et al. Cell-specific haploinsufficiency of TNF receptor p55 enables safe and effective TNF-based antitumor therapy
    J. Clin. Invest., 123, 2590-2603, 2013.
  5. Vandevyver et al. Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation
    J. Clin. Invest., 122, 2130, 2012.

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