Tel: +32 9 33 13 761
Fax: +32 9 221 76 73
Our research aims to understand the in vivo mechanisms by which inflammation drives (autoimmune) pathology. For these studies we make use of Cre/LoxP-mediated gene targeting technology allowing tissue-specific gene deletion in mice, in combination with mouse models of human inflammatory diseases. Central in our research is the study of the molecular mechanisms involving NF-κB, apoptosis and ER stress in pathologies such as inflammatory bowel disease, rheumatoid arthritis, diabetes and multiple sclerosis.