Rudi Beyaert lab
Prof. dr. Rudi Beyaert
Email: rudi.beyaert@vib-ugent.be
Main research topics
- Functional characterization of novel candidate IBD genes (R. Beyaert is spokesperson of the Excellence of Science (EOS) programme “Taking IBD Genes from GWAS to Function to Drug Target” (BRIDGE))
- Crosstalk between epithelial cells and immune cells in gut, skin and lung inflammation
- Molecular and cellular mechanisms involved in intestinal transit and constipation (subteam I. Afonina)
- Metabolic engineering of probiotic yeast for efficient delivery of anti-inflammatory metabolites to the gut (subteam J. Staal)
- CBM signaling and MALT1 protease activity in inflammation, immunity and cancer
- Inborn errors of immunity in chronic inflammation and immunodeficiency
- Development and preclinical validation of novel cytokine antagonists
Areas of expertise: Inflammation, Immunity, Cancer
- Cytokines (TNF, IL-1, IL-33, IL-35)
- Toll-like receptors
- Molecular biology and immunology
- Intracellular signaling (NF-κB, STAT, MAP kinases, …)
- Protein-protein interactions; phosphorylation and ubiquitination
- T cell and epithelial cell biology
- Advanced flow cytometry immunophenotyping
- Mouse gene targeting and models of human disease (IBD, constipation, colorectal cancer, psoriasis, MS, asthma)
